Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 21-40 of 580
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An investigation into the effects of current immunosuppressants and novel compounds on animal models of asthma and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Asthma is a disease with a worldwide distribution and of increasing prevalence. There are two forms of the disease; intrinsic, which is believed to follow a Th1 cytokine profile and extrinsic, which follows a Th2 response. ... -
An investigation of the impact of experimental colitis and inflammatory bowel disease on behaviour and on systemic and central inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Inflammatory bowel diseases (IBD) are chronic conditions characterised by uncontrolled inflanmiation of the intestinal mucosa. Clinical symptoms include weight loss, diarrhoea, rectal bleeding and abdominal pain. In addition ... -
An investigation of the potential anti-inflammatory properties of novel compounds with respect to LFA-1 mediated T cell motility and cytotoxicity profiling
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The aim of this thesis was to investigate the effects in vitro of novel compounds on LFA-1 mediated T cell motility, and, to develop a profile of the compounds with respect to cytotoxicity and apoptosis. The compounds ... -
An investigation of the role of the polyamines in epilepsy and cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)The polyamines, spermine and spermidine, are ubiquitous in nature but are found in especially high concentrations in brain tissue. The polyamines are required for cell growth and differentiation but in high doses are ... -
An investigation on the therapeutic properties of novel compounds in models of asthma, inflammation and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)There are many drugs on the market for the treatment of asthma, inflammation and delayed type hypersensitivity (DTH), however few are disease modifying. The potential therapeutic effect of three novel compounds, 3C8, 6C6 ... -
An investigation to optimise teicoplanin therapy in patients with haematological malignancy and Gram-positive infection
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)This research was prompted by concerns of Tallaght Hospital, a major teaching hospital in Dublin, Ireland, that the dosage regimen for teicoplanin in patients with haematological malignancy was suboptimal. Three studies ... -
Analysis of platelet function: role of microfluidics and nanodevices
(2011)Platelet aggregation is essential for vascular haemostasis and thrombosis. To improve the therapy of arterial thrombotic disorders and identify novel therapeutic targets it is imperative to study basic mechanisms of platelet ... -
Anti-Inflammatory Activity of Choisya ternata Kunth Essential Oil, Ternanthranin, and Its Two Synthetic Analogs (Methyl and Propyl N-Methylanthranilates)
(2015)Choisya ternata Kunth (Rutaceae) is native to North America where it is popularly known as "Mexican orange". In this study, the anti-inflammatory effects of the essential oil (EO) obtained from the leaves of C. ternata , ... -
Anti-inflammatory activity of ethanol extract and fractions from Couroupita guianensis Aublet leaves.
(2013)Abstract Ethnopharmacological relevance Couroupita guianensis Aublet, ‘macacarecuia’, ‘abricó-de-macaco’, ‘castanha-de-macaco’ and ‘amêndoa-dos-andes’, is found in tropical regions and is widely used in the treatment ... -
Anticrystal Engineering of Ketoprofen and Ester Local Anesthetics: Ionic Liquids or Deep Eutectic Mixtures?
(2020)Ionic liquids (ILs) and deep eutectic mixtures (DEMs) are potential solutions to the problems of low solubility, polymorphism, and low bioavailability of drugs. The aim of this work was to develop and investigate ketoprofen ... -
Antinociceptive activity of Cistanche salsa stolons, growing in the Republic of Kazakhstan
(2017)Herba Cistanche (Cistanche species) in Traditional Chinese Medicine is used for the treatment of several diseases and symptoms, to include pain. The objective of this study was to evaluate the antinociceptive effect of the ... -
Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil
(2016)Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO).Themajor component ... -
Antioxidant activity from the leaf extracts of Jacaranda puberula Cham., Bignoniaceae, a Brazilian medicinal plant used for blood depuration
(2010)The antioxidant activity of leaf extracts from Jacaranda puberula Cham., Bignoniaceae, was assayed by the DPPH (2,2-diphenyl-1-picryl-hydrazyl) free radical scavenging method. Three phytomedicines (F1, F2, and F3) used as ... -
The antiviral potential of algal-derived macromolecules
(2021)A diverse range of molecules with anticancer, antiviral, and antibiotic activities has been identified and isolated from algal species. Such metabolites could address unmet clinical needs and be used to fight human diseases. ... -
Approaches to Drying Hydrated Active Pharmaceutical Ingredients (APIs).
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)This project aims to develop a drying protocol that removes unwanted moisture from hydrated APIs while preserving water of hydration. Hydrate forms of model compounds, carbamazepine and theophylline, were generated with ... -
Approaches to the safety assessment of engineered nanomaterials (ENM) in food
(Elsevier, 2011)A systematic, tiered approach to assess the safety of engineered nanomaterials (ENMs) in foods is presented. The ENM is first compared to its non-nano form counterpart to determine if ENM-specific assessment is required. ...
