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dc.contributor.authorMc Crory, Cathal
dc.date.accessioned2019-05-03T07:30:24Z
dc.date.available2019-05-03T07:30:24Z
dc.date.issued2019
dc.date.submitted2019en
dc.identifier.citationMcCrory, C., Fiorito, G., Ni Cheallaigh, C., Polidoro, S., Karisola, P., Alenius, H., Layte, R., Seeman, T., Vineis, P. & Kenny, RA., How does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s)., Psychoneuroendocrinology, 104, 2019, 64 - 73en
dc.identifier.otherY
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0306453018310631
dc.identifier.urihttp://hdl.handle.net/2262/86711
dc.descriptionPUBLISHEDen
dc.description.abstractIndividuals of lower socio-economic position (SEP) carry a heavier burden of disease and morbidity and live shorter lives on average compared with their more advantaged counterparts. This has sparked research interest in the processes and mechanisms via which social adversity gets biologically embedded. The present study directly compares the empirical worth of two candidate mechanisms: Allostatic Load (AL) and the Epigenetic Clock(s) for advancing our understanding of embodiment using a sub-sample of 490 individuals from the Irish Longitudinal Study (TILDA) who were explicitly selected for this purpose based on their inter-generational life course social class trajectory. A battery of 14 biomarkers representing the activity of 4 different physiological systems: Immunological, Cardiovascular, Metabolic, and Renal was used to construct the AL score. Biomarkers were dichotomised into high and low risk groups according to sex-specific quartiles of clinical risk and summed to create a count ranging from 0-14. Three measures of epigenetic age acceleration were computed according to three sets of age-associated Cytosine-phosphate-Guanine (CpG) sites described by Horvath, Hannum and Levine. AL was strongly socially patterned across a number of measures of SEP, while the epigenetic clocks were not. AL partially mediated the association between measures of SEP and an objective measure of physiological functioning: performance on the Timed Up and Go (TUG test). We conclude that AL may represent the more promising candidate for understanding the pervasive link between SEP and health.en
dc.format.extent64en
dc.format.extent73en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesPsychoneuroendocrinology;
dc.relation.ispartofseries104;
dc.rightsYen
dc.subjectSocioeconomic Positionen
dc.subjectEpigenetic Clocken
dc.subjectAllostatic Loaden
dc.subjectBiological Embeddingen
dc.subjectLife Courseen
dc.titleHow does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s)en
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board (HRB)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mccrorc
dc.identifier.rssinternalid201041
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberEIA-2017-012en
dc.relation.sourceTILDAen
dc.subject.TCDThemeAgeingen
dc.subject.TCDThemeInclusive Societyen
dc.subject.TCDTagEpidemiologyen
dc.identifier.rssurihttps://doi.org/10.1016/j.psyneuen.2019.02.018
dc.subject.darat_thematicHealthen
dc.subject.darat_thematicPovertyen
dc.subject.darat_thematicThird age/ageingen
dc.status.accessibleNen
dc.rights.restrictedAccessY
dc.date.restrictedAccessEndDate2019-07-01


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