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dc.contributor.advisorPrendergast., Patrick J.
dc.contributor.authorKelly, Daniel John
dc.date.accessioned2019-05-02T16:11:05Z
dc.date.available2019-05-02T16:11:05Z
dc.date.issued2004
dc.identifier.citationDaniel John Kelly, 'Mechanobiology of tissue differentiation during osteochondral defect repair', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004, pp 211
dc.identifier.otherTHESIS 7515
dc.identifier.urihttp://hdl.handle.net/2262/86684
dc.description.abstractDifferentiation can be thought of as a process by which cells and tissues undergo a change in phenotype toward a more specialized form or function. It is the contention of this thesis that tissue differentiation is in some way regulated by the mechanical environment of the cells within the tissue. A theoretical model was developed which relates the dispersal, proliferation, and death of cells, and their subsequent differentiation, to their mechanical environment. In an attempt to confirm this mechano-regulation hypothesis, an algorithm based on the theoretical model was developed and used to simulate tissue differentiation during spontaneous osteochondral defect repair, where the mechanical environment within the defect was determined using finite element modelling. The influence of a number of physical factors, such as defect size and loading, were studied by altering these parameters in the finite element model. Furthermore, the influence of implanting a scaffold or engineered cartilage tissue on osteochondral defect repair was examined, where the mechanical properties of tissue engineered cartilage was determined experimentally.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12426524
dc.subjectMechanical and Manufacturing Engineering, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleMechanobiology of tissue differentiation during osteochondral defect repair
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 211
dc.description.noteTARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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