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dc.contributor.advisorWolfe, Ken
dc.contributor.authorWong, Simon
dc.date.accessioned2019-05-02T11:29:18Z
dc.date.available2019-05-02T11:29:18Z
dc.date.issued2004
dc.identifier.citationSimon Wong, 'Comparative genomics in yeasts', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2004, pp 151
dc.identifier.otherTHESIS 7529
dc.identifier.urihttp://hdl.handle.net/2262/86670
dc.description.abstractComparative genomics allows us to delve into the fundamental differences among species that form the basis of biodiversity, as well as the preservative forces of natural selection that have left many things unchanged. It is important to understand how these opposing influences ultimately shaped the genomes of today. The yeast Saccharomyces cerevisiae and its relatively small, completely sequenced genome is an ideal model eukaryote for such research. With the availability of sequence data from a wide range of related yeasts, this study re-visited the controversial proposal that S. cerevisiae is derived from an ancient polyploid. A novel technique of visualising gene order data between species, 'proximity plots', was created. It uncovered extensive duplicated regions in the S. cerevisiae genome that were previously undetected. The organisation of these blocks reaffirmed the genome duplication hypothesis. Computer simulation was used to predict post-polyploidisation gene order conservation under a gradual diploidisation model, which can explain most of the observed data.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Genetics
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12426527
dc.subjectGenetics, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleComparative genomics in yeasts
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 151
dc.description.noteTARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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