Neurotrophin mRNA expression in the central nervous system of the brain stem-spinal cord regenerating model, Anguilla anguilla, the European eel
Citation:
Victoria Stephanie Peart, 'Neurotrophin mRNA expression in the central nervous system of the brain stem-spinal cord regenerating model, Anguilla anguilla, the European eel', [thesis], Trinity College (Dublin, Ireland). Department of Zoology, 2007, pp 250Download Item:
Peart TCD THESIS 8085 Neurotrophin mRNA.pdf (PDF) 150.9Mb
Abstract:
Neuronal regeneration is extremely limited in the central nervous system (CNS) of
mature amniotes. On the other hand, many anamniotes, such as some fish, display rapid
morphological and functional recovery after CNS injury, a process that has often been
compared to neuronal development. Neurotrophins are a group of molecules that are
crucial in development, as well as in the maintenance and plasticity of the adult nervous
system. They are also thought to play an important role in neuronal regeneration.
Neurotrophin mRNA and protein are upregulated in the cell bodies and target regions of
injured neurons that lie in the mammalian peripheral nervous system (PNS), and which do
regenerate after axonal injury. Neurotrophins are also present in the anamniote CNS but
little is known about their spatial expression patterns or their involvement in regeneration
after neuronal insult in this group of animals. Based on the results of mammalian studies,
the hypothesis was formulated that neurotrophin expression may be upregulated in the
anamniote CNS after injury in order to aid in neuronal regeneration. To test this
hypothesis, neurotrophin and neurotrophin receptor mRNA expression was investigated in
the eel CNS at various timepoints before and after spinal cord transection, and during
regeneration and functional recovery.
Author: Peart, Victoria Stephanie
Advisor:
Borich, SuzanneRoberts, Barry
Qualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of ZoologyNote:
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Full text availableKeywords:
Zoology, Ph.D., Ph.D. Trinity College DublinLicences: