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dc.contributor.advisorLynch, Marina
dc.contributor.authorMinogue, Aedín
dc.date.accessioned2019-05-01T13:35:48Z
dc.date.available2019-05-01T13:35:48Z
dc.date.issued2005
dc.identifier.citationAedín Minogue, 'Analysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2005, pp 351
dc.identifier.otherTHESIS 7564
dc.identifier.urihttp://hdl.handle.net/2262/86508
dc.description.abstractLong-term potentiation (LTP) is considered to be a possible neurophysiological model for learning and memory and consistent with this, is the observation that LTP is sensitive to stress, injury and insult. This thesis investigates the effects of amyloid- β (Aβ) and subsequent cellular signalling pathways on expression of LTP in perforant-path granule cell synapses. Evidence suggests that an age-related impairment in LTP exists in hippocampus and that upregulation of proinflammatory signalling may underpin this effect. This observation indicates that hippocampus may be more susceptible to stress or insult with age. Consequently, the effects of Aβ administration on LTP in hippocampus of adult and aged rats was investigated.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Microbiology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12438723
dc.subjectMicrobiology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleAnalysis of the effects of Beta-Amyloid and age on cell signalling in rat hippocampus : effect of treatment with polyunsaturated fatty acids
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 351
dc.description.noteTARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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