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dc.contributor.advisorMantle, Tim
dc.contributor.authorFranklin, Edward
dc.date.accessioned2019-04-30T08:38:50Z
dc.date.available2019-04-30T08:38:50Z
dc.date.issued2006
dc.identifier.citationEdward Franklin, 'Kinetic studies on biliverdin-IXalpha reductase', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006, pp 331
dc.identifier.otherTHESIS 7990
dc.identifier.urihttp://hdl.handle.net/2262/86334
dc.description.abstractThe species distribution of biliverdin-IXa reductase (BVR-A) has been reinvestigated. It appears increasingly likely that birds and amphibia have the potential to express an active biliverdin-IXa reductase. The full length cDNAs encoding human, Danio rerio, murine, and Xenopus BVR-A were successfully amplified and cloned into various expression vectors. To date human BVR-A pET41a-Mod, murine BVR-A ppMAL, and Xenopus BVR-A pGEX-KG transformed cultures have been induced with IPTG resulting in the expression of recombinant proteins which display the appropriate molecular weights. The cloning and expression of an active Xenopus BVR-A in this study and the detection of biliverdin reductase activity in turkey erythrocyte cytosol extends the phylogenetic distribution of BVR-A to include amphibians and possibly birds.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Biochemistry and Immunology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb13031890
dc.subjectBiochemistry, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleKinetic studies on biliverdin-IXalpha reductase
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 331
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