dc.contributor.advisor | Bell, Angus | |
dc.contributor.author | Cunningham, Eithne | |
dc.date.accessioned | 2019-04-29T15:18:47Z | |
dc.date.available | 2019-04-29T15:18:47Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Eithne Cunningham, 'Investigation of Plasmodium falciparum aminopeptidases and characterisation of the M17 leucine aminopeptidase', [thesis], Trinity College (Dublin, Ireland). Department of Microbiology, 2008, pp 213 | |
dc.identifier.other | THESIS 8563 | |
dc.identifier.uri | http://hdl.handle.net/2262/86280 | |
dc.description.abstract | Plasmodium falciparum spends part of its life cycle residing in human erythrocytes,
during which time it digests much of the host cell haemoglobin to provide a source of
amino acids for synthesis of its own proteins. The final stages of digestion are thought to
be carried out by aminopeptidases that cleave amino acids from the N -termini of peptides.
The inhibition of aminopeptidase activity can disrupt parasite development, implicating
this group of enzymes as a possible drug target. Novel targets for antimalarial drugs are
greatly needed due to the high rate of mortality associated with the disease and the
emergence of resistance to existing treatments. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Microbiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb13438503 | |
dc.subject | Microbiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Investigation of Plasmodium falciparum aminopeptidases and characterisation of the M17 leucine aminopeptidase | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 213 | |
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