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dc.contributor.authorZisterer, Daniela
dc.contributor.authorFederico, Stefano
dc.contributor.authorKhan, Tuhina
dc.contributor.authorRelitti, Nicola
dc.contributor.authorChemi, Giulia
dc.contributor.authorBrindisi, Margherita
dc.contributor.authorBrogi, Simone
dc.contributor.authorNovellino, Ettore
dc.contributor.authorCampiani, Giuseppe
dc.contributor.authorGemma, Sandra
dc.contributor.authorButini, Stefania
dc.date.accessioned2018-11-30T09:05:46Z
dc.date.available2018-11-30T09:05:46Z
dc.date.issued2018en
dc.date.submitted2018en
dc.identifier.citationDaniela Zisterer, Stefano Federico, Tuhina Khan, Nicola Relitti, Giulia Chemi, Margherita Brindisi, Simone Brogi, Ettore Novellino, Giuseppe Campiani, Sandra Gemma, Stefania Butini, 'A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents', 2018, Tetrahedron Letters;en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/85445
dc.descriptionACCEPTEDen
dc.description.abstractWe developed a Jocic-type protocol for the construction of the pyrrolonaphthoxazepine (PNOX) core. After an initial investigation based on the isolation of a trichloromethyl carbinol derivative, we shifted our attention towards a multicomponent single-step protocol. Screening of a variety of bases and solvents led to the identification of the optimum conditions for the preparation of the key a-aryloxy carboxylic acids to undergo intramolecular cyclization. The novel chemical route significantly improved overall yields for the preparation of PNOX-based compounds and was successfully extended to the preparation of 1,4-benzoxazinone-based templates.en
dc.description.sponsorshipEuropean Commission Horizon 2020 Marie Sklodowska-Curie Grant agreement No 721906.en
dc.language.isoenen
dc.relation.ispartofseriesTetrahedron Letters;
dc.rightsYen
dc.subjectPyrrolonaphthoxazepinesen
dc.subjectapoptosisen
dc.subjectheterocyclesen
dc.subjectanti-tumouren
dc.titleA Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agentsen
dc.typeJournal Articleen
dc.contributor.sponsorEuropean Commissionen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/dzistrer
dc.identifier.rssinternalid193366
dc.identifier.doihttps://doi.org/10.1016/j.tetlet.2018.11.005
dc.relation.ecprojectidinfo:eu-repo/grantAgreement/EC/FP7/MSCA ITN grant No 721906.
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberMSCA ITN grant No 721906.en
dc.subject.TCDThemeCanceren
dc.identifier.orcid_id0000-0001-5005-1023
dc.status.accessibleNen


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