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dc.contributor.advisorBennett, Kathleen
dc.contributor.authorSpillane, Susan Catherine
dc.date.accessioned2018-11-29T17:03:16Z
dc.date.available2018-11-29T17:03:16Z
dc.date.issued2013
dc.identifier.citationSusan Catherine Spillane, 'Metformin, aspirin, and colorectal cancer outcomes', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2013, pp 239
dc.identifier.otherTHESIS 10344
dc.identifier.urihttp://hdl.handle.net/2262/85437
dc.description.abstractColorectal cancer is the second most incident cancer in men and women in Ireland and is the third greatest cause of cancer death. Metformin and aspirin, two drugs which are commonly used in type 2 diabetes and cardiovascular disease, have been identified as having a potential role in the treatment of colorectal cancer. Preclinical studies have demonstrated an inhibitory effect on colorectal tumours with each drug, and a range of potential mechanisms of action for their anti-cancer effects have been proposed. Metformin may act to inhibit colorectal tumours through direct actions on cancer cells or may have an indirect effect through insulin-related signalling pathways. Similarly, aspirin may have a direct effect by inhibiting the COX-2 enzyme in cancer cells, or may act to prevent tumour spread through mechanisms related to platelet inhibition.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15662072
dc.subjectPharmacology and Therapeutics, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleMetformin, aspirin, and colorectal cancer outcomes
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 239
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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