Show simple item record

dc.contributor.advisorCassidy, Lorraine
dc.contributor.advisorCahill, Mark
dc.contributor.authorNi Dhubhghaill, Sorcha S.
dc.date.accessioned2018-11-29T16:45:00Z
dc.date.available2018-11-29T16:45:00Z
dc.date.issued2011
dc.identifier.citationSorcha S. Ni Dhubhghaill, 'Genetic and environmental risk factors in age-related macular degeneration in vitro, in vivo and population studies', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011, pp 228
dc.identifier.otherTHESIS 10017
dc.identifier.urihttp://hdl.handle.net/2262/85422
dc.description.abstractThe aims of this project are to show the potential sites of interaction between underlying genetic susceptibilities and environmental influences (cigarette smoke) in neovascular AMD. Our current hypothesis proposes that cigarette smoke exerts its toxic effects by altering the expression of vasoactive proteins at the level of the RPE, ultimately promoting angiogenesis. To test this we used in vitro and in vivo menthods. We also consider the possibility that known genetic risk factors in regions coding for vasoactive proteins may contribute to this process of angiogenesis in Irish patients with AMD. [exerpt Page 69]
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15349560
dc.subjectClinical Medicine, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleGenetic and environmental risk factors in age-related macular degeneration in vitro, in vivo and population studies
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 228
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record