Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer
Citation:Niamh Lynam-Lennon, 'Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011, pp 345
Lynam Lennon TCD THESIS 9307 Investigation of.pdf (PDF) 197.6Mb
The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant clinical problem, with only ~30% of patients achieving a complete pathological response. Radiation therapy exerts its effects locoregionally, consequently, in terms of locoregional control, tumour resistance to radiation therapy may predominantly contribute to treatment failure. The identification of biomarkers and molecular mechanism(s) of radioresistance is central to facilitating patient treatment stratification, improving survival rates and identifying novel targets to enhance the efficacy of radiation therapy.
Author: Lynam-Lennon, Niamh
Pidgeon, Graham P.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery
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Type of material:thesis
Availability:Full text available