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dc.contributor.advisorSheils, Orla
dc.contributor.authorDorris, Emma R.
dc.date.accessioned2018-11-29T15:29:26Z
dc.date.available2018-11-29T15:29:26Z
dc.date.issued2013
dc.identifier.citationEmma R. Dorris, 'Molecular mechanisms of resistance to therapeutic MEK inhibition in BRAF [V600E] cancer', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013, pp 208
dc.identifier.otherTHESIS 10155
dc.identifier.urihttp://hdl.handle.net/2262/85398
dc.description.abstractAberrant activation of the mitogen activated protein kinase (MAPK) pathway is common in solid tumours. This hierarchical pathway consists of a three-tiered kinase casade of BRAF, MAPK kinase (MEK1/2) and the extracellular signal-regulated kinase (ERK1/2). Extracellular ligands activate the pathway by binding to receptors on the cell surface that signal through the small GTRase RAS to recruit and activate BRAF, which initiates a kinase cascade through MEK1/2 and ERK1/2 to activate downstream transcription factors involved in a range of biochemical processes including differentiation, proliferation, growth and survival. Mutations in BRAF occur at an estimated rate of 50-80% melanoma and 45% in thyroid carcinoma. The most common BRAF mutation is a single base pair change, T1799A, that results in a valine to glutamic acid change at position 600 in the BRAF polypeptide (BRAF V600E). This causes a conformational change in the BRAF protein leading to constitutive activation and oncogene addiction to the MAPK pathway.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15355774
dc.subjectMolecular Medicine, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleMolecular mechanisms of resistance to therapeutic MEK inhibition in BRAF [V600E] cancer
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 208
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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