Browsing Genetics by Author "BRADLEY, DANIEL"
Now showing items 1-18 of 18
- Sort by:
- title
- issue date
- submit date
- Order:
- ascending
- descending
- Results:
- 5
- 10
- 20
- 40
- 60
- 80
- 100
-
Angiogenin Levels and ANG Genotypes: Dysregulation in Amyotrophic Lateral Sclerosis
PHUKAN, JULIE; BRADLEY, DANIEL; HARDIMAN, ORLA; MCLAUGHLIN, RUSSELL; MCLAUGHLIN, RUSSELL (2010)Objective: To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF. Methods: Allelic ... -
Definition of the cattle killer cell Ig-like receptor gene family: Comparison with aurochs and human counterparts
BRADLEY, DANIEL (2014)Under selection pressure from pathogens, variable NK cell receptors that recognize polymorphic MHC class I evolved convergently in different species of placental mammal. Unexpectedly, diversified killer cell Ig–like receptors ... -
Genetic and expression analysis of cattle identifies candidate genes in pathways responding to Trypanosoma congolense infection.
BRADLEY, DANIEL (2011)African bovine trypanosomiasis caused by Trypanosoma sp., is a major constraint on cattle productivity in sub-Saharan Africa. Some African Bos taurus breeds are highly tolerant of infection, but the potentially more ... -
Genetic evidence of African slavery at the beginning of the Trans-Atlantic slave trade
BRADLEY, DANIEL (2014)An archaeological excavation in Valle da Gafaria (Lagos, Portugal), revealed two contiguous burial places outside the medieval city walls, dating from the 15th-17th centuries AD: one was interpreted as a Leprosarium cemetery ... -
Genome-wide association study for calving traits in Holstein-Friesian dairy cattle
BRADLEY, DANIEL (2014)The enteropathogen Campylobacter jejuni is a major worldwide health and economic burden, being one of the leading causes of bacterial gastroenteritis and commonly linked to postinfectious onset of autoimmune disease. ... -
A genome-wide association study for genetic susceptibility to Mycobacterium bovis infection in dairy cattle identifies a susceptibility QTL on chromosome 23
BRADLEY, DANIEL (2016)Background Bovine tuberculosis (bTB) infection in cattle is a significant economic concern in many countries, with annual costs to the UK and Irish governments of approximately €190 million and €63 million, respectively, ... -
A genome-wide association study for somatic cell score using the Illumina high-density bovine beadchip identifies several novel QTL potentially related to mastitis susceptibility
BRADLEY, DANIEL (2013)Mastitis is an inflammation-driven disease of the bovine mammary gland that occurs in response to physical damage or infection and is one of the most costly production-related diseases in the dairy industry worldwide. We ... -
Genomic signals of migration and continuity in Britain before the Anglo-Saxons
BRADLEY, DANIEL; HARDIMAN, ORLA; MCLAUGHLIN, RUSSELL (2016)The purported migrations that have formed the peoples of Britain have been the focus of generations of scholarly controversy. However, this has not benefited from direct analyses of ancient genomes. Here we report nine ... -
How Much Is That in Dog Years? The Advent of Canine Population Genomics
BRADLEY, DANIEL (2014)ABSTRACT The authors comment on two studies that analyzed multiple genomes of dogs and wolves. The studies reached different conclusions about the date and population effects, a disparity attributed to reliance on molecular ... -
Meta-Analysis of mitochondrial DNA reveals several population bottlenecks during worldwide migrations of cattle
BRADLEY, DANIEL (2014)Several studies have investigated the differentiation of mitochondrial DNA in Eurasian, African and American cattle as well as archaeological bovine material. A global survey of these studies shows that haplogroup distributions ... -
MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhanced by microRNA regulation of endocytosis and lysosome trafficking
BRADLEY, DANIEL (2015)Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first ... -
Microsatellite genotyping of medieval cattle from central Italy suggests an old origin of Chianina and Romagnola cattle
BRADLEY, DANIEL (2015)Analysis of DNA from archeological remains is a valuable tool to interpret the history of ancient animal populations. So far most studies of ancient DNA target mitochondrial DNA (mtDNA), which reveals maternal lineages, ... -
The Neolithic Transition in the Baltic Was Not Driven by Admixture with Early European Farmers
BRADLEY, DANIEL (2017) -
Paging through history: Parchment as a reservoir of ancient DNA for next generation sequencing
BRADLEY, DANIEL (2015)Parchment represents an invaluable cultural reservoir. Retrieving an additional layer of information from these abundant, dated livestock-skins via the use of ancient DNA (aDNA) sequencing has been mooted by a number of ... -
Revisiting AFLP fingerprinting for an unbiased assessment of genetic structure and differentiation of taurine and zebu cattle
BRADLEY, DANIEL (2014)Background Descendants from the extinct aurochs (Bos primigenius), taurine (Bos taurus) and zebu cattle (Bos indicus) were domesticated 10,000 years ago in Southwestern and Southern Asia, respectively, and colonized the ... -
Sequencing and analysis of an Irish human genome.
BRADLEY, DANIEL; HARDIMAN, ORLA (2010)Background: Recent studies generating complete human sequences from Asian, African and European subgroups have revealed population-specific variation and disease susceptibility loci. Here, choosing a DNA sample from a ... -
Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle
BRADLEY, DANIEL (2014)Open Access Research Variance components for susceptibility to Mycobacterium bovis infection in dairy and beef cattle Ian W Richardson12, Dan G Bradley1, Isabella M Higgins3, Simon J More3, Jennifer McClure4 and Donagh ... -
A whole mitochondria analysis of the Tyrolean Iceman's leather provides insights into the animal sources of Copper Age clothing
BRADLEY, DANIEL (2016)The attire of the Tyrolean Iceman, a 5,300-year-old natural mummy from the Ötzal Italian Alps, provides a surviving example of ancient manufacturing technologies. Research into his garments has however, been limited by ...