Browsing Obstetrics & Gynaecology by Author "O'Leary, John"
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Circulating tumour cells: The Good, the Bad and the Ugly.
Ward, Mark; O'Toole, Sharon; O'Leary, John; Malone, Victoria; O'Connor, R?is?n (2023)This review is an overview of the current knowledge regarding circulating tumour cells (CTCs), which are potentially the most lethal type of cancer cell, and may be a key component of the metastatic cascade. The clinical ... -
Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens
Norris, Lucy; O'Leary, John; Kelly, Lynne (Elsevier, 2010)Recent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their ... -
Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening.
Norris, Lucy; Martin, Cara; O'Leary, John; Finn, Stephen; O'Toole, Sharon; Sheils, Orla; Abu Saadeh, Feras; Flavin, Richard; Kelly, Lynne (2013)Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) ...