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dc.contributor.authorBOWIE, ANDREW
dc.date.accessioned2018-01-24T17:00:13Z
dc.date.available2018-01-24T17:00:13Z
dc.date.issued2017
dc.date.submitted2017en
dc.identifier.citationSisquella, X. and Ofir-Birin, Y. and Pimentel, M.A. and Cheng, L. and Abou Karam, P. and Sampaio, N.G. and Penington, J.S. and Connolly, D. and Giladi, T. and Scicluna, B.J. and Sharples, R.A. and Waltmann, A. and Avni, D. and Schwartz, E. and Schofield, L. and Porat, Z. and Hansen, D.S. and Papenfuss, A.T. and Eriksson, E.M. and Gerlic, M. and Hill, A.F. and Bowie, A.G. and Regev-Rudzki, N., Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors, Nature Communications, 8, 1, 2017, 1985-en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/82273
dc.description.abstractSTING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite ( Plasmodium falciparum ) or other pathogen DNA. As P. falciparum infects red blood cells and not leukocytes, how parasite DNA reaches such host cytosolic DNA sensors in immune cells is unclear. Here we show that malaria parasites inside red blood cells can engage host cytosolic innate immune cell receptors from a distance by secreting extracellular vesicles (EV) containing parasitic small RNA and genomic DNA. Upon internalization of DNA- harboring EVs by human monocytes, P. falciparum DNA is released within the host cell cytosol, leading to STING-dependent DNA sensing. STING subsequently activates the kinase TBK1, which phosphorylates the transcription factor IRF3, causing IRF3 to translocate to the nucleus and induce STING-dependent gene expression. This DNA-sensing pathway may be an important decoy mechanism to promote P. falciparum virulence and thereby may affect future strategies to treat malaria.en
dc.format.extent1985en
dc.language.isoenen
dc.relation.ispartofseriesNature Communications;
dc.relation.ispartofseries8;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectMalariaen
dc.titleMalaria parasite DNA-harbouring vesicles activate cytosolic immune sensorsen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/agbowie
dc.identifier.rssinternalid182127
dc.identifier.doihttp://dx.doi.org/10.1038/s41467-017-02083-1
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber11/PI/1056en
dc.identifier.orcid_id0000-0001-5316-4373


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