Show simple item record

dc.contributor.authorO'NEILL, LUKE
dc.date.accessioned2018-01-24T12:23:42Z
dc.date.available2018-01-24T12:23:42Z
dc.date.issued2017
dc.date.submitted2017en
dc.identifier.citationMenon, D. and Innes, A. and Oakley, A.J. and Dahlstrom, J.E. and Jensen, L.M. and Br??stle, A. and Tummala, P. and Rooke, M. and Casarotto, M.G. and Baell, J.B. and Nguyen, N. and Xie, Y. and Cuellar, M. and Strasser, J. and Dahlin, J.L. and Walters, M.A. and Burgio, G. and O'Neill, L.A.J. and Board, P.G., GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity, Scientific Reports, 7, 1, 2017en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/82255
dc.description.abstractGlutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of Gsto1 alters the response of mice to three distinct inflammatory disease models. GSTO1-1 deficiency ameliorates the inflammatory response stimulated by LPS and attenuates the inflammatory impact of a high fat diet on glucose tolerance and insulin resistance. In contrast, GSTO1-1 deficient mice show a more severe inflammatory response and increased escape of bacteria from the colon into the lymphatic system in a dextran sodium sulfate mediated model of inflammatory bowel disease. These responses are similar to those of TLR4 and MyD88 deficient mice in these models and confirm that GSTO1-1 is critical for a TLR4-like pro-inflammatory response in vivo . In wild-type mice, we show that a small molecule inhibitor that covalently binds in the active site of GSTO1-1 can be used to ameliorate the inflammatory response to LPS. Our findings demonstrate the potential therapeutic utility of GSTO1-1 inhibitors in the modulation of inflammation and suggest their possible application in the treatment of a range of inflammatory conditions.en
dc.language.isoenen
dc.relation.ispartofseriesScientific Reports;
dc.relation.ispartofseries7;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectGlutathione transferase Omega 1 (GSTO1-1)en
dc.titleGSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesityen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/laoneill
dc.identifier.rssinternalid182230
dc.identifier.doihttp://dx.doi.org/10.1038/s41598-017-17861-6
dc.rights.ecaccessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record