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dc.contributor.authorCORVIN, AIDENen
dc.contributor.authorLOPEZ, LORNAen
dc.contributor.authorDONOHOE, GARYen
dc.date.accessioned2017-08-15T11:21:56Z
dc.date.available2017-08-15T11:21:56Z
dc.date.issued2017en
dc.date.submitted2017en
dc.identifier.citationHibar, D.P., Adams, H.H.H., Jahanshad, N., (...), Thompson, P.M., Ikram, M.A., Novel genetic loci associated with hippocampal volume, Nature Communications, 8, 2017, 13624en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/81688
dc.descriptionPUBLISHEDen
dc.description.abstractThe hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease (rg=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.en
dc.format.extent13624en
dc.relation.ispartofseriesNature Communicationsen
dc.relation.ispartofseries8en
dc.rightsYen
dc.titleNovel genetic loci associated with hippocampal volumeen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/acorvinen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/donoghugen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/halihanlen
dc.identifier.rssinternalid175685en
dc.identifier.doihttp://dx.doi.org/10.1038/ncomms13624en
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0001-6717-4089en


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