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dc.contributor.advisorO'Leary, John
dc.contributor.advisorMartin, Cara
dc.contributor.authorSoyingbe, Itunu Senami O.
dc.date.accessioned2017-06-28T09:54:01Z
dc.date.available2017-06-28T09:54:01Z
dc.date.issued2014
dc.identifier.citationItunu Senami O. Soyingbe, 'The silencing of HPV16 Oncogenes using E6siRNAs', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2014, pp 312
dc.identifier.otherTHESIS 10473
dc.identifier.urihttp://hdl.handle.net/2262/80516
dc.description.abstractCervical cancer is the fourth most common cancer worldwide and remains a rising cause of cancer deaths amongst women worldwide, particularly in low to mid-income countries. High risk HPV is the main etiological factor in cervical carcinogenesis. The overexpression of high risk HPV E6 and E7 due to viral genome integration and loss of high risk E2 is the key factor in this disease progression. These oncogenes subvert cellular tumour suppressor genes (p53 and unphosphorylated pRB) and create a neoplastic environment that facilitates increased cellular alterations that promote malignancy.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15994702
dc.subjectHistopathology and Morbid Anatomy, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe silencing of HPV16 Oncogenes using E6siRNAs
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 312
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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