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dc.contributor.advisorRyan, Thomas
dc.contributor.authorGrealy, Christopher Robert
dc.date.accessioned2017-05-15T14:35:46Z
dc.date.available2017-05-15T14:35:46Z
dc.date.issued2014
dc.identifier.citationChristopher Robert Grealy, 'Gene expression profiling in patients with severe sepsis', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014, pp 216
dc.identifier.otherTHESIS 10778
dc.identifier.urihttp://hdl.handle.net/2262/80055
dc.description.abstractThe human response to infection ranges from mild illness which is relatively well tolerated to a severe, potentially life-threatening syndrome termed severe sepsis. This thesis explored this response in patients hospitalised patients with mild or non-septic infection and severe sepsis. Distinct patterns of particular cytokine mRNA levels were observed in circulating peripheral blood mononuclear cells from patients admitted to intensive care with severe sepsis compared to patients with non-septic infection not requiring intensive care. A means to quantify the degree of immune dysfunction through these assays is put forward. The basis of these changes in cytokine mRNA levels is investigated through ex vivo mechanistic studies. Genome wide transcriptional changes are evaluated in two populations of circulating mononuclear cells, namely the CD14* monocyte and the CD4+ lymphocyte.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb16204253
dc.subjectSurgery, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleGene expression profiling in patients with severe sepsis
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 216
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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