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dc.contributor.authorWHELAN, ROBERTen
dc.contributor.authorGARAVAN, HUGHen
dc.contributor.authorO'CONNELL, REDMONDen
dc.date.accessioned2017-04-19T12:23:21Z
dc.date.available2017-04-19T12:23:21Z
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationNick Ortiz, Aisling Parsons, Robert Whelan, Katie Brennan, Maria LF Agan, Redmond O Connell, Jessica Bramham, Hugh Garavan, Decreased frontal, striatal and cerebellar activation in adults with ADHD during an adaptive delay discounting task, Acta Neurobiol Exp, 75, 2015, 326 - 338en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/79854
dc.descriptionPUBLISHEDen
dc.description.abstractAn important characteristic of childhood attention-deficit/hyperactivity disorder (ADHD) is a bias towards small immediate versus larger delayed rewards, but it is not known if this symptom is also a feature of adult ADHD. A delay-discounting task was administered to participants with adult ADHD and a comparison group in conjunction with functional magnetic resonance imaging. Participants responded to a series of questions that required judgments between small sums of money available immediately and larger sums obtained after a temporal delay. Question parameters were adjusted by an adaptive algorithm designed to converge on each participant's discounting indifference point, an individual set point at which there is equal valuation of both choices. In all participants, robust task activation was observed in regions previously identified in functional imaging studies of delay discounting. However, adults with ADHD showed less task activation in a number of regions including the dorsolateral prefrontal cortex, superior frontal gyrus, anterior cingulate, caudate nucleus and declive of the cerebellum. Additionally, the degree to which a participant discounted delayed rewards was inversely related to task activation in the cerebellum. The results suggest that the bias towards immediate rewards in childhood ADHD may not persist behaviorally, but instead present in adulthood as alterations in frontostriatal and frontocerebellar networks.en
dc.format.extent326en
dc.format.extent338en
dc.relation.ispartofseriesActa Neurobiol Expen
dc.relation.ispartofseries75en
dc.rightsYen
dc.subjectADHDen
dc.titleDecreased frontal, striatal and cerebellar activation in adults with ADHD during an adaptive delay discounting tasken
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/whelanr3en
dc.identifier.peoplefinderurlhttp://people.tcd.ie/reoconneen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/garavanhen
dc.identifier.rssinternalid148767en
dc.rights.ecaccessrightsopenAccess
dc.identifier.rssurihttp://wvvw.ane.pl/pdf/7527.pdfen
dc.identifier.orcid_id0000-0002-2790-7281en


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