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dc.contributor.authorWalsh, Cathalen
dc.contributor.authorBoran, Gerarden
dc.contributor.authorNolan, Johnen
dc.date.accessioned2017-04-19T11:16:50Z
dc.date.available2017-04-19T11:16:50Z
dc.date.created2015en
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationSinnott M, Kinsley B.T, Jackson A.D, Walsh C, O'Grady T, Nolan J.J, Gaffney P, Boran G, Kelleher C, Carr B, Fasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The diabetes mellitus and vascular health initiative (DMVhi), PLoS ONE, 10, 4, 2015en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/79845
dc.descriptionPUBLISHEDen
dc.descriptionCited By :6 Export Date: 19 April 2017en
dc.description.abstractOBJECTIVE: Type 2 diabetes has a long pre clinical asymptomatic phase. Early detection may delay or arrest disease progression. The Diabetes Mellitus and Vascular health initiative (DMVhi) was initiated as a prospective longitudinal cohort study on the prevalence of undiagnosed Type 2 diabetes and prediabetes, diabetes risk and cardiovascular risk in a cohort of Irish adults aged 45-75 years. RESEARCH DESIGN AND METHODS: Members of the largest Irish private health insurance provider aged 45 to 75 years were invited to participate in the study. EXCLUSION CRITERIA: already diagnosed with diabetes or taking oral hypoglycaemic agents. Participants completed a detailed medical questionnaire, had weight, height, waist and hip circumference and blood pressure measured. Fasting blood samples were taken for fasting plasma glucose (FPG). Those with FPG in the impaired fasting glucose (IFG) range had a 75gm oral glucose tolerance test performed. RESULTS: 122,531 subjects were invited to participate. 29,144 (24%) completed the study. The prevalence of undiagnosed diabetes was 1.8%, of impaired fasting glucose (IFG) was 7.1% and of impaired glucose tolerance (IGT) was 2.9%. Dysglycaemia increased among those aged 45-54, 55-64 and 65-75 years in both males (10.6%, 18.5%, 21.7% respectively) and females (4.3%, 8.6%, 10.9% respectively). Undiagnosed T2D, IFG and IGT were all associated with gender, age, blood pressure, BMI, abdominal obesity, family history of diabetes and triglyceride levels. Using FPG as initial screening may underestimate the prevalence of T2D in the study population. CONCLUSIONS: This study is the largest screening study for diabetes and prediabetes in the Irish population. Follow up of this cohort will provide data on progression to diabetes and on cardiovascular outcomes.en
dc.relation.ispartofseriesPLoS ONEen
dc.relation.ispartofseries10en
dc.relation.ispartofseries4en
dc.rightsYen
dc.subjectDiabetesen
dc.titleFasting plasma glucose as initial screening for diabetes and prediabetes in irish adults: The diabetes mellitus and vascular health initiative (DMVhi)en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/walshcen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jnolanen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/borangpen
dc.identifier.rssinternalid158677en
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0122704en
dc.rights.ecaccessrightsopenAccess
dc.identifier.rssurihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84929486152&doi=10.1371%2fjournal.pone.0122704&partnerID=40&md5=22f2cc96fc6d0d3173de37cd004e3891en


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