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dc.contributor.advisorMartin, Seamus J.
dc.contributor.authorCarroll, Richard
dc.date.accessioned2017-02-23T15:18:15Z
dc.date.available2017-02-23T15:18:15Z
dc.date.issued2015
dc.identifier.citationRichard Carroll, 'The role of Bcl-2 family in mitochondrial homeostasis', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2015, pp 180
dc.identifier.otherTHESIS 10861
dc.identifier.urihttp://hdl.handle.net/2262/79518
dc.description.abstractMitochondria are required by cells to generate ATP in order to meet their energy requirements. The electron transport chain, within the mitochondria, pumps protons into the intermembrane space generating an electrochemical gradient. This electrochemical gradient is required for production of ATP and is referred to as the mitochondrial potential. During apoptosis, the activation of Bax/Bak results in a loss of mitochondrial potential and a release of cytochrome c into the cytosol. The loss of mitochondrial potential is the critical step that commits a cell to dying. However, release of cytochrome c activates the apoptosis cascade and promotes a non-inflammatory mode of cell death as opposed to the inflammatory mode of cell death, necrosis.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Genetics
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb16257201
dc.subjectGenetics, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe role of Bcl-2 family in mitochondrial homeostasis
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 180
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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