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dc.contributor.advisorDoherty, Derek
dc.contributor.authorO'Reilly, Vincent
dc.date.accessioned2017-02-08T12:38:44Z
dc.date.available2017-02-08T12:38:44Z
dc.date.issued2013
dc.identifier.citationVincent O'Reilly, 'Investigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets', [thesis], Trinity College (Dublin, Ireland). Department of Immunology, 2013, pp 256
dc.identifier.otherTHESIS 9875
dc.identifier.urihttp://hdl.handle.net/2262/79297
dc.description.abstractInvariant natural killer T (iNKT) cells comprise a rare subset of T cells that recognise glycolipid antigens presented by CDld. Activation of iNKT cells in mice leads to protection against cancer, autoimmune disease and infection in numerous murine models of disease. Based on the very promising results observed in murine models, clinical trials have been undertaken with cancer patients, but to date have been somewhat disappointing. The best results were obtained using a combination therapy of adoptively transferred dendritic cells (DC) pulsed with the prototypical iNKT cell ligand, alpha galactosylceramide (aGalCer) along with ex vivo expanded iNKT cells.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Immunology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15319291
dc.subjectImmunology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleInvestigation of the phenotypes, functions and therapeutic potential of expanded human invariant natural killer T cell subsets
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 256
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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