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dc.contributor.advisorLynch, Marina
dc.contributor.authorJones, Raasay
dc.date.accessioned2017-01-19T15:30:36Z
dc.date.available2017-01-19T15:30:36Z
dc.date.issued2012
dc.identifier.citationRaasay Jones, 'A role for amyloid-β in Alzheimer's pathology : evidence from cellular, animal and pre-clinical studies', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2012, pp 340
dc.identifier.otherTHESIS 10091
dc.identifier.urihttp://hdl.handle.net/2262/79061
dc.description.abstractOne of the well-documented histopathological features of Alzheimer’s disease (AD) is the progressive accumulation of amyloid-β (Aβ) within the brain, thought to result from inefficient clearance of Aβ by phagocytes and/or increased processing of amyloid precursor protein (APP). While neuroinflammatory changes, largely mediated by glial cells, are believed to be intricately involved in the pathogenesis of this chronic neurodegenerative disorder, the effect of inflammation on Aβ clearance remains to be firmly established. One of the primary objectives of this study was to assess the impact of exogenous and endogenous Aβ on microglia and astrocytes both in vitro and in vivo, with a specific interest in analysing its effect on astrocytes.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Physiology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15355077
dc.subjectPhysiology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleA role for amyloid-β in Alzheimer's pathology : evidence from cellular, animal and pre-clinical studies
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 340
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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