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dc.contributor.advisorDev, Kumlesh
dc.contributor.authorHealy, Luke M.
dc.date.accessioned2017-01-19T11:55:05Z
dc.date.available2017-01-19T11:55:05Z
dc.date.issued2012
dc.identifier.citationLuke M. Healy, 'The regulation of sphingosine-1-phosphate 1 receptor signalling and trafficking in astrocytes : implications for Multiple Sclerosis', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2012, pp 181
dc.identifier.otherTHESIS 10054
dc.identifier.urihttp://hdl.handle.net/2262/79042
dc.description.abstractMultiple Sclerosis (MS) is a chronic, inflammatory and autoimmune disease of the central nervous system (CNS). Fingolimod (FTY720-P) is an immunomodulatory drug recently granted FDA approval for the treatment of remitting relapsing MS. This compound is a pro-drug and an analogue of sphingosine-1-phosphate (S1P), an important lipid mediator that is implicated in a wide range of biological processes. The clinical benefits of FTY720-P have been attributed to its modulation of a group of G- protein coupled receptors (GPCRs) which naturally bind S1P. Internalisation of these S1P receptors by binding of FTY720-P limits entry of autoreactive T-cells into brain tissue.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Physiology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15352277
dc.subjectPhysiology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe regulation of sphingosine-1-phosphate 1 receptor signalling and trafficking in astrocytes : implications for Multiple Sclerosis
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 181
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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