dc.contributor.advisor | Dev, Kumlesh | |
dc.contributor.author | Healy, Luke M. | |
dc.date.accessioned | 2017-01-19T11:55:05Z | |
dc.date.available | 2017-01-19T11:55:05Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Luke M. Healy, 'The regulation of sphingosine-1-phosphate 1 receptor signalling and trafficking in astrocytes : implications for Multiple Sclerosis', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2012, pp 181 | |
dc.identifier.other | THESIS 10054 | |
dc.identifier.uri | http://hdl.handle.net/2262/79042 | |
dc.description.abstract | Multiple Sclerosis (MS) is a chronic, inflammatory and autoimmune disease of the central nervous system (CNS). Fingolimod (FTY720-P) is an immunomodulatory drug recently granted FDA approval for the treatment of remitting relapsing MS. This compound is a pro-drug and an analogue of sphingosine-1-phosphate (S1P), an important lipid mediator that is implicated in a wide range of biological processes. The clinical benefits of FTY720-P have been attributed to its modulation of a group of G- protein coupled receptors (GPCRs) which naturally bind S1P. Internalisation of these S1P receptors by binding of FTY720-P limits entry of autoreactive T-cells into brain tissue. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). Department of Physiology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15352277 | |
dc.subject | Physiology, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | The regulation of sphingosine-1-phosphate 1 receptor signalling and trafficking in astrocytes : implications for Multiple Sclerosis | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 181 | |
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