Molecular devices based on reversible singlet oxygen binding in optical and photomedical applications.
Citation:
Filatov, M. A.; Senge, M. O., Molecular devices based on reversible singlet oxygen binding in optical and photomedical applications., Molecular Systems Design & Engineering, 1, 2016, 258 272.Download Item:

Abstract:
Polycyclic aromatic hydrocarbons are known to bind singlet oxygen with formation of endoperoxides,
which can be released upon heating. This process is now capturing broad attention due to its potential in
photomedicine. Singlet oxygen generation upon decomposition of endoperoxides at ambient temperatures
represents an alternative to classical photodynamic therapy (PDT), which is limited by hypoxia and reduced
light penetration into cancer tissue. Moreover, endoperoxide formation with chromophoric molecules allows
for a straightforward modification of the optical properties of the photoactive materials, e.g., shifting
of the absorption/emission wavelength which is usually achieved by chemical tuning. This review provides
a summary of the latest advances in this area of research along with a discussion of the basic properties of
organic endoperoxides.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
14/ TIDA/2362
Science Foundation Ireland (SFI)
13/IA/1894
Author's Homepage:
http://people.tcd.ie/sengemDescription:
PUBLISHED
Author: SENGE, MATHIAS
Type of material:
Journal ArticleCollections:
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Molecular Systems Design & Engineering1
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Full text availableDOI:
http://dx.doi.org/10.1039/C6ME00042HLicences: