Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes'
Item Type:Journal Article
Citation:Calatrava-PÃ©rez E, Bright S.A, Achermann S, Moylan C, Senge M.O, Veale E.B, Williams D.C, Gunnlaugsson T, Scanlan E.M, Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes', Chemical Communications, 52, 89, 2016, 13086 - 13089
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Glycosylated 4-amino-1,8-naphthalimide derivatives possess a native glycosidic linkage that can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide as a fluorescent imaging or therapeutic agent. In vitro studies using a variety of cancer cell lines demonstrated that the naphthalimides only get taken up into cells upon enzymatic cleavage from the glycan unit; a mechanism that offers a novel approach for the targeted delivery of probes/drugs.
Science Foundation Ireland (SFI)
PI 2013 13/IA/1865
Export Date: 8 December 2016
Type of material:Journal Article
Series/Report no:Chemical Communications
Availability:Full text available