Show simple item record

dc.contributor.advisorDev, Kumlesh
dc.contributor.authorDeb, Debadutta
dc.date.accessioned2017-01-18T12:15:25Z
dc.date.available2017-01-18T12:15:25Z
dc.date.issued2012
dc.identifier.citationDebadutta Deb, 'The role of parkin-picki in mithchondrial dysfunction', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2012, pp 243
dc.identifier.otherTHESIS 9749
dc.identifier.urihttp://hdl.handle.net/2262/78878
dc.description.abstractAutosomal Recessive Juvenile Parkinsonism (ARJP) is the most common motor-related neurodegenerative disease, which occurs in young adults between 20-40 years of age. Mutations in the parkin (PARK2) gene are associated ARJP, which result in the loss of dopaminergic neurons of substantia nigra pars compacta in the mid brain. Parkin, an E3 ligase, is an enzyme responsible for ubiquitination of several proteins leading to their degradation in Ubiquitin Proteasomal System (UPS) and promoting autophagy of depolarized mitochondria. Mutations in the parkin gene are thought to result in protein aggregation of parkin substrates resulting in neuronal toxicity. Among these parkin interacting proteins and substrates, several play important roles in mitochondrial function, oxidative stress, cellular toxicity and apoptosis. This project focused on investigating the role of one particular protein that interacts with parkin, namely, PICK1. Specifically, the studies herein investigated the role of a parkin-PICK1 interaction in mitochondrial function and oxidative stress.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Physiology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15157581
dc.subjectPhysiology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe role of parkin-picki in mithchondrial dysfunction
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 243
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record