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dc.contributor.advisorFallon, Padraic
dc.contributor.authorCluxton, Christopher
dc.date.accessioned2017-01-18T11:49:03Z
dc.date.available2017-01-18T11:49:03Z
dc.date.issued2012
dc.identifier.citationChristopher Cluxton, 'Evolutionary origins and functions of Schistosoma mansoni Pellino', [thesis], Trinity College (Dublin, Ireland). Department of Immunology, 2012, pp 310
dc.identifier.otherTHESIS 10111
dc.identifier.urihttp://hdl.handle.net/2262/78845
dc.description.abstractThe immune system of modern man has innate signalling pathways that arose in ancestral species. This is exemplified by the discovery of the Toll-like receptor (TLR) pathway using free-living model organisms, specifically Drosophila, as well as Caenorhabditis elegans. Here, we use the helminth parasite Schistosoma mansoni, which has adapted to reside within the vasculature of man, to explore homologous signalling pathways in a co-evolving system using the innate signalling Pellino protein. Pellino proteins are highly conserved E3 ubiquitin ligases that mediate activation of NF-kB and MAPK pathways.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Immunology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15355291
dc.subjectImmunology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleEvolutionary origins and functions of Schistosoma mansoni Pellino
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 310
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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