Show simple item record

dc.contributor.advisorRoche, Helen
dc.contributor.authorMoloney, Fiona
dc.date.accessioned2016-12-15T15:54:55Z
dc.date.available2016-12-15T15:54:55Z
dc.date.issued2006
dc.identifier.citationFiona Moloney, 'Conjugated lineolic acid and insulin sensitivity : insights from metabolic and molecular markers', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006, pp 316
dc.identifier.otherTHESIS 7871
dc.identifier.urihttp://hdl.handle.net/2262/78516
dc.description.abstractInsulin resistance signifies an impaired biological response to insulin, and usually implies resistance to the effects of insulin on glucose uptake, metabolism, or storage. This defect is commonly observed in type 2 diabetes mellitus (T2DM) and the metabolic syndrome and is often found in association with other cardiovascular disease (CVD) risk factors including obesity, dyslipidaemia, hypertension and atherosclerosis. Altering the composition of fat in the diet can have a profound effect on insulin sensitivity whereby saturated fatty acids attenuate insulin sensitivity, while monounsaturated fatty acids can reverse this effect. The objective of this thesis was to examine the relationship between the n-6 polyunsaturated fatty acid conjugated linoleic acid (CLA) and insulin sensitivity, and its possible involvement in attenuating other risk factors associated with CVD. Several isoforms of CLA exist with cis-9, trans-11 CLA (c9, t11-CLA) which is the predominant dietary isoform and trans-10, cis-12 CLA (t10, c12-CLA) thought to have most biological activity.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12715499
dc.subjectMolecular Medicine, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleConjugated lineolic acid and insulin sensitivity : insights from metabolic and molecular markers
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 316
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record