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dc.contributor.advisorWalsh, John
dc.contributor.authorZhang, Tao
dc.date.accessioned2016-12-05T17:04:47Z
dc.date.available2016-12-05T17:04:47Z
dc.date.issued2010
dc.identifier.citationTao Zhang, 'The synthesis of novel mast cell stabilisers from benzocycloalkanones', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010, pp 441
dc.identifier.otherTHESIS 9287
dc.identifier.urihttp://hdl.handle.net/2262/78259
dc.description.abstractThe purpose of this project was to design and synthesise novel classes of mast cell stabilisers from benzocycloalkanones. This thesis is introduced with an overview of the increasing prevalence of allergic conditions throughout the world, and the fiindamental role mast cells and their associated mediators play in allergic reactions. The mechanism of the interaction between the antibody, immunoglobulin E (IgE), and its cell surface high affinity IgE-Fc receptors (FcεRI) is outlined. There then follows a review of numerous preformed and newly synthesized inflammatory mediators which are released by the activated mast cells following allergen subsequent exposure. This leads on to a discussion of the consequent pathological effects of these biological mediators in; allergic diseases, autoimmune disorders and inflammatory conditions. Chapter 1 concludes with an assessment of both currently available and investigational therapeutic options in the treatment of these mast cell-mediated diseases.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14862969
dc.subjectPharmacy, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe synthesis of novel mast cell stabilisers from benzocycloalkanones
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 441
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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