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dc.contributor.advisorMeegan, Mary Jane
dc.contributor.authorO'Sullivan, Mary
dc.date.accessioned2016-12-01T16:18:48Z
dc.date.available2016-12-01T16:18:48Z
dc.date.issued2005
dc.identifier.citationMary O'Sullivan, 'The synthesis and biochemical evaluation of novel isoquinoline derivatives', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005, pp 372
dc.identifier.otherTHESIS 7743
dc.identifier.urihttp://hdl.handle.net/2262/78162
dc.description.abstractIsoquinolines are naturally occurring alkaloids, some of which have pharmacological activity. Previous work by the research group of Dr. Mary Jane Meegan, has shown diverse classes of isoquinoline derivatives to be active against monoamine oxidase and acetylcholinesterase. This provided pointers to structure-activity relationships, leading to the syntheses undertaken in this study. Chapter One discusses current theories on the aetiology of depression, Parkinson’s Disease and Alzheimer’s Disease. Current clinical treatments are outlined, and the possible roles of monoamine oxidase and acetylcholinesterase inhibitors are placed in context. The current understanding of the structure of monoamine oxidase is summarised. The rationale for work to be undertaken is then presented.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12458301
dc.subjectPharmaceutical Chemistry, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe synthesis and biochemical evaluation of novel isoquinoline derivatives
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 372
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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