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dc.contributor.advisorGilmer, John
dc.contributor.authorO'Byrne, Paul Matthew
dc.date.accessioned2016-12-01T14:48:16Z
dc.date.available2016-12-01T14:48:16Z
dc.date.issued2010
dc.identifier.citationPaul Matthew O'Byrne, 'Pharmaceutical stability and prodrug studies on the antidepressant bupropion', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010, pp 286
dc.identifier.otherTHESIS 9276
dc.identifier.urihttp://hdl.handle.net/2262/78137
dc.description.abstractThis thesis describes the work carried out at the School of Pharmacy and Pharmaceutical Sciences, Trinity College on the pharmaceutical stability and prodrug studies on the antidepressant bupropion. Chapter 1 gives an overview of bupropion, discussing its therapeutic uses, pharmacokinetics, adverse effects and pharmacology. The prodrug concept is introduced with particular reference to central nervous system brain delivery and prodrug options relating to these types. Prodrugs of bupropion would be advantageous to improve its stability and side-effect profile. Chapter 2 addresses the aqueous stability of bupropion with particular emphasis on the kinetics of degradation. The pH rate profile of bupropion shows instability above pH 5 and this problem can be addressed by prodrug design.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14735874
dc.subjectPharmacy, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titlePharmaceutical stability and prodrug studies on the antidepressant bupropion
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 286
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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