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dc.contributor.advisorCorrigan, Owen I.
dc.contributor.advisorTajber, Lidia
dc.contributor.authorLi, Xue
dc.date.accessioned2016-12-01T10:22:22Z
dc.date.available2016-12-01T10:22:22Z
dc.date.issued2009
dc.identifier.citationXue Li, 'Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009, pp 307
dc.identifier.otherTHESIS 8712
dc.identifier.urihttp://hdl.handle.net/2262/78055
dc.description.abstractThe current study involved the preparation of a range of micro and nano particulates from known biocompatible pharmaceutical polymeric excipients: PLGA, chitosan and hyaluronic acid, using physical rather than chemical processes and evaluates the various aspects of their drug delivery potential, biointeraction and potential toxicity. Emulsion techniques, including the double emulsion and single emulsion technique, are methods usually used in the manufacture of drug loaded PLGA (RG504) particles, as well as chitosan-PLGA particles. Cationically modified PLGA particles can efficiently bind the negatively charged DNA electrostatically, by using chitosan as adjuvant (Kumbar et al., 2002). Although release studies of proteins and drugs have been reported by numerous groups (Pean et al., 1998; Dunne et al., 2000; Gallagher and Corrigan 2000), there were large differences between the results. Therefore it is deemed necessary to explain the differences and conclude on the effects.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb13900396
dc.subjectPharmaceutics, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleFormulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 307
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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