Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery
Citation:Xue Li, 'Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009, pp 307
Li TCD THESIS 8712 Formulation, production.pdf (PDF) 155.1Mb
The current study involved the preparation of a range of micro and nano particulates from known biocompatible pharmaceutical polymeric excipients: PLGA, chitosan and hyaluronic acid, using physical rather than chemical processes and evaluates the various aspects of their drug delivery potential, biointeraction and potential toxicity. Emulsion techniques, including the double emulsion and single emulsion technique, are methods usually used in the manufacture of drug loaded PLGA (RG504) particles, as well as chitosan-PLGA particles. Cationically modified PLGA particles can efficiently bind the negatively charged DNA electrostatically, by using chitosan as adjuvant (Kumbar et al., 2002). Although release studies of proteins and drugs have been reported by numerous groups (Pean et al., 1998; Dunne et al., 2000; Gallagher and Corrigan 2000), there were large differences between the results. Therefore it is deemed necessary to explain the differences and conclude on the effects.
Author: Li, Xue
Advisor:Corrigan, Owen I.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
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Type of material:thesis
Availability:Full text available