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dc.contributor.advisorHealy, Anne-Marie
dc.contributor.authorGeraghty, Martina Ann
dc.date.accessioned2016-11-29T15:30:55Z
dc.date.available2016-11-29T15:30:55Z
dc.date.issued2004
dc.identifier.citationMartina Ann Geraghty, 'Investigation of ibuprofen release from ethylcellulose matrix compacts', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004, pp 390
dc.identifier.otherTHESIS 7454
dc.identifier.urihttp://hdl.handle.net/2262/77991
dc.description.abstractA comprehensive study of ethylcellulose powder and ethylcellulose compacts (of different ethylcellulose viscosity grades) was undertaken. Studies showed that the lower viscosity grade ethylcellulose (4 cP) was more compressible than the higher ethylcellulose viscosity grades, resulting in compacts of higher tensile strength and lower compact porosity. These differences, in addition to differences such as surface roughness, water uptake and contact angle (with phosphate buffer) affected the release of ibuprofen from ethylcellulose:ibuprofen compacts prepared with different ethylcellulose viscosity grades. The effect of ethylcellulose viscosity grade and polymer-to-drug weight ratio on ibuprofen release from ethylcellulose:ibuprofen compacts was investigated. Results showed that the higher the ethylcellulose viscosity grade used during formulation the greater the percentage drug release. Experiments also found that as the level of drug concentration in the ethylcellulose ; ibuprofen matrix formulation increased, the drug release rate also increased. It was thought that the increase in drug concentration resulted in an increase in compact porosity and a concomitant decrease in the tortuosity of the matrix. Percolation theory was also used to explain the change in dissolution kinetics of the matrix controlled release system over the range of drug loadings examined.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12392918
dc.subjectPharmaceutics, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleInvestigation of ibuprofen release from ethylcellulose matrix compacts
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 390
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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