Show simple item record

dc.contributor.advisorO'Driscoll, Lorraine
dc.contributor.authorCorcoran, Claire
dc.date.accessioned2016-11-29T11:47:01Z
dc.date.available2016-11-29T11:47:01Z
dc.date.issued2013
dc.identifier.citationClaire Corcoran, 'Intracellular and extracellular biomarkers predictive of response to anti-cancer treatments for breast and prostate cancer', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013, pp 297
dc.identifier.otherTHESIS 10347
dc.identifier.urihttp://hdl.handle.net/2262/77929
dc.description.abstractCancer remains one of the leading causes of death worldwide. Breast and prostate cancer are the most frequently diagnosed cancers among women and men, respectively. Despite some breakthroughs in their treatment, innate or acquired-resistance hinders the continued success of some treatments. Through the initial use of breast cancer cell lines with acquired- or innate-resistance to trastuzumab, lapatinib and later assessing neratinib and afatinib, this PhD investigated the mechanisms behind resistance to these therapies. Similarly, the mechanisms involved in regulating docetaxel-resistance in prostate cancer cell lines were also investigated. The second focus of this PhD involved testing the hypothesis that the extracellular environment may carry biomarkers representative of their cells of origin, thus offering the potential of identifying biomarkers in a minimally- invasive manner.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15662169
dc.subjectPharmacy & Pharmaceutical Sciences, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleIntracellular and extracellular biomarkers predictive of response to anti-cancer treatments for breast and prostate cancer
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 297
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record