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dc.contributor.advisorCorrigan, Owen I.
dc.contributor.authorByrne, Thomas Stephen
dc.date.accessioned2016-11-28T17:00:40Z
dc.date.available2016-11-28T17:00:40Z
dc.date.issued2002
dc.identifier.citationThomas Stephen Byrne, 'Warfarin therapy in the Republic of Ireland : the potential role of neural networks in optimising therapy', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002, pp 379
dc.identifier.otherTHESIS 6917
dc.identifier.urihttp://hdl.handle.net/2262/77902
dc.description.abstractAnticoagulant therapy is used to reduce the embolic risk associated with many diseases e.g. atrial fibrillation, deep vein thrombosis and aortic valve replacement. The decision to anticoagulate a patient is made individually, taking into account the potential benefits and risks. Warfarin is the only oral anticoagulant licensed in the Republic of Ireland. It has a very narrow therapeutic index and for safe rational anticoagulant therapy, an understanding of the interrelationships which influence an individual’s response to the drug is essential. The objective of this study was to investigate the potential role that neural networks (NNs) may play in oral anticoagulant therapy. NNs are computer based mathematical modelling systems that mimic the computational ability of the human brain. In order to improve the quality of patient care, we considered the possibility of using NNs to mimic the prescribing behaviour of the health care practitioners (HCP) in the anticoagulant clinic (AC) of the Adelaide and Meath Hospital incorporating the National Children’s Hospital (AMNCH). An additional role for NNs to predict patients’ International Normalised Ratio (INR) measurements upon return to the AC was also investigated.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12429435
dc.subjectPharmacy, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleWarfarin therapy in the Republic of Ireland : the potential role of neural networks in optimising therapy
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 379
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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