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dc.contributor.advisorHealy, Anne-Marie
dc.contributor.advisorTajber, Lidia
dc.contributor.authorBianco, Stefano
dc.date.accessioned2016-11-24T17:12:35Z
dc.date.available2016-11-24T17:12:35Z
dc.date.issued2013
dc.identifier.citationStefano Bianco, 'The effect of processing on the solid state characteristis of selected sulphonamides and their sodium salts, alone and as drug-salt composites', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013, pp 232
dc.identifier.otherTHESIS 9896
dc.identifier.urihttp://hdl.handle.net/2262/77866
dc.description.abstractThe purpose of the research presented in this thesis was to produce metastable active pharmaceutical ingredients (API) by spray drying and to analyse, physico-chemically characterise these forms and develop strategies to enhance their physical stability. The solid state properties of two spray dried drugs and their sodium salt forms together with co-spray dried API/salt composites were investigated and compared to the unprocessed materials. The drugs investigated were the sulphonamide compounds, sulfadimidine and sulfathiazole. The compounds were spray dried from water, ethanol, acetone and mixtures of these organic solvents with water. The methods of analysis employed to characterise the resulting spray dried powders were conventional and modulated differential scanning calorimetry (DSC/MTDSC), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), attenuated total reflectance-FTIR (ATR-FTIR) and powder X-ray diffraction (PXRD). Surface properties were analysed by inverse gas chromatography (IGC) and morphology by scanning electron microscopy. Hygroscopic properties and water interactions were studied by dynamic vapour sorption (DVS).
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15325978
dc.subjectPharmaceutics, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe effect of processing on the solid state characteristis of selected sulphonamides and their sodium salts, alone and as drug-salt composites
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 232
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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