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dc.contributor.advisorEhrhardt, Carsten
dc.contributor.authorBaginski, Eve Leonie
dc.date.accessioned2016-11-24T16:54:13Z
dc.date.available2016-11-24T16:54:13Z
dc.date.issued2011
dc.identifier.citationEve Leonie Baginski, 'Optimisation of pulmonary drug delivery of the model peptide drug, salmon calcitonin', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011, pp 189
dc.identifier.otherTHESIS 9548
dc.identifier.urihttp://hdl.handle.net/2262/77855
dc.description.abstractThe use of the pulmonary route is a viable alternative administration route to injection, in particular for drugs with poor systemic bioavailability upon oral delivery such as therapeutic peptides and proteins. However, information about the expression and activity of metabolic enzymes (e.g., peptidases) on disposition of biopharmaceuticals after inhalation is critically missing. This information could help to better understand, if protective measures such as PEGylation, chemical modification or peptidase inhibitors are meaningful for pulmonary delivery of biotechnology medicines. It was the aim of this work to investigate the role of peptidases in pulmonary drug delivery of a model peptide drug, salmon calcitonin (sCT), and to find a suitable formulation for improved pulmonary drug delivery of this peptide. In a first step, mRNA expression levels of selected catabolising peptidases were determined in human lung epithelial cells. The proteolytic enzymes (i.e., carboxypeptidases; CPA1, CPA2, CPB, CPM; gamma-glutamyltransferases: GGT1,
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15116424
dc.subjectPharmacy, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleOptimisation of pulmonary drug delivery of the model peptide drug, salmon calcitonin
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 189
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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