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dc.contributor.authorHarkin, Andrewen
dc.date.accessioned2016-09-27T09:41:45Z
dc.date.available2016-09-27T09:41:45Z
dc.date.issued2016en
dc.date.submitted2016en
dc.identifier.citationHughes M.M, Connor T.J, Harkin A, Stress-Related Immune Markers in Depression: Implications for Treatment, International Journal of Neuropsychopharmacology, 19, 6, 2016, 1 - 19en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/77425
dc.descriptionPUBLISHEDen
dc.descriptionExport Date: 26 September 2016en
dc.description.abstractMajor depression is a serious psychiatric disorder; however, the precise biological basis of depression still remains elusive. A large body of evidence implicates a dysregulated endocrine and inflammatory response system in the pathogenesis of depression. Despite this, given the heterogeneity of depression, not all depressed patients exhibit dysregulation of the inflammatory and endocrine systems. Evidence suggests that inflammation is associated with depression in certain subgroups of patients and that those who have experienced stressful life events such as childhood trauma or bereavement may be at greater risk of developing depression. Consequently, prolonged exposure to stress is thought to be a key trigger for the onset of a depressive episode. This review assesses the relationship between stress and the immune system, with a particular interest in the mechanisms by which stress impacts immune function, and how altered immune functioning, in turn, may lead to a feed forward cascade of multiple systems dysregulation and the subsequent manifestation of depressive symptomology. The identification of stress-related immune markers and potential avenues for advances in therapeutic intervention is vital. Changes in specific biological markers may be used to characterize or differentiate depressive subtypes or specific symptoms and may predict treatment response, in turn facilitating a more effective, targeted, and fast-acting approach to treatment.en
dc.description.sponsorshipM.H. was supported by a TCD School of Medicine Translational Neuroscience grant. The authors also acknowledge support from the EU FP7-funded MOODINFLAME consortium.en
dc.format.extent1en
dc.format.extent19en
dc.relation.ispartofseriesInternational Journal of Neuropsychopharmacologyen
dc.relation.ispartofseries19en
dc.relation.ispartofseries6en
dc.rightsYen
dc.subjectdepressionen
dc.subject.lcshdepressionen
dc.titleStress-Related Immune Markers in Depression: Implications for Treatmenten
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/aharkinen
dc.identifier.rssinternalid127886en
dc.identifier.doihttp://dx.doi.org/10.1093/ijnp/pyw001en
dc.rights.ecaccessrightsopenAccess
dc.identifier.rssurihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84979895374&partnerID=40&md5=88ead5a433ea7655b9e86a41fb4b8943en
dc.identifier.orcid_id0000-0001-9734-216Xen


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