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dc.contributor.authorREILLY, RICHARDen
dc.contributor.authorWALTON, CLAIRen
dc.date.accessioned2016-09-19T14:24:00Z
dc.date.available2016-09-19T14:24:00Z
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationButler JS, Beiser IM, Williams L, McGovern E, Molloy F, Lynch T, Healy DG, Moore H, Walsh R, Reilly RB, O'Riordan S, Walsh C, Hutchinson M, Age-Related Sexual Dimorphism in Temporal Discrimination and in Adult-Onset Dystonia Suggests GABAergic Mechanisms., Frontiers in neurology, 6, 2015, 258en
dc.identifier.issn1664-2295en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/77382
dc.descriptionPUBLISHEDen
dc.description.abstractBACKGROUND: Adult-onset isolated focal dystonia (AOIFD) presenting in early adult life is more frequent in men, whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult-onset idiopathic isolated focal dystonia, shows evidence of sexual dimorphism in healthy participants. OBJECTIVES: We assessed the distinctive features of age-related sexual dimorphism of (i) sex ratios in dystonia phenotypes and (ii) sexual dimorphism in temporal discrimination in unaffected relatives of cervical dystonia patients. METHODS: We performed (i) a meta-regression analysis of the proportion of men in published cohorts of phenotypes of adult-onset dystonia in relation to their mean age of onset and (ii) an analysis of temporal discrimination thresholds in 220 unaffected first-degree relatives (125 women) of cervical dystonia patients. RESULTS: In 53 studies of dystonia phenotypes, the proportion of men showed a highly significant negative association with mean age of onset (p < 0.0001, pseudo-R (2) = 59.6%), with increasing female predominance from 40 years of age. Age of onset and phenotype together explained 92.8% of the variance in proportion of men. Temporal discrimination in relatives under the age of 35 years is faster in women than men but the age-related rate of deterioration in women is twice that of men; after 45 years of age, men have faster temporal discrimination than women. CONCLUSION: Temporal discrimination in unaffected relatives of cervical dystonia patients and sex ratios in adult-onset dystonia phenotypes show similar patterns of age-related sexual dimorphism. Such age-related sexual dimorphism in temporal discrimination and adult-onset focal dystonia may reflect common underlying mechanisms. Cerebral GABA levels have been reported to show similar age-related sexual dimorphism in healthy participants and may be the mechanism underlying the observed age-related sexual dimorphism in temporal discrimination and the sex ratios in AOIFD.en
dc.format.extent258en
dc.relation.ispartofseriesFrontiers in neurologyen
dc.relation.ispartofseries6en
dc.rightsYen
dc.subjectadult-onset isolated focal dystoniaen
dc.subjectpenetranceen
dc.subjectsex ratioen
dc.subjectsexual dimorphismen
dc.subjecttemporal discriminationen
dc.titleAge-Related Sexual Dimorphism in Temporal Discrimination and in Adult-Onset Dystonia Suggests GABAergic Mechanisms.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/reillyrien
dc.identifier.peoplefinderurlhttp://people.tcd.ie/cwaltonen
dc.identifier.rssinternalid124165en
dc.identifier.doihttp://dx.doi.org/10.3389/fneur.2015.00258en
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0001-8578-1245en


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