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dc.contributor.authorDUNCAN, HALen
dc.contributor.authorMORAN, GARYen
dc.contributor.authorFLEMING, GARRYen
dc.date.accessioned2016-08-25T15:48:31Z
dc.date.available2016-08-25T15:48:31Z
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationDuncan HF, Smith AJ, Fleming GJP, Moran GP, Cooper PR., Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points , Genomic Data, 5, 2015, 391 - 393en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/76893
dc.descriptionPUBLISHEDen
dc.description.abstractDental pulp tissue can be damaged by a range of irritants, however, if the irritation is removed and/or the tooth is adequately restored, pulp regeneration is possible (Mjör and Tronstad, 1974 [1]). At present, dental restorative materials limit healing by impairing mineralization and repair processes and as a result new biologically-based materials are being developed (Ferracane et al., 2010 [2]). Previous studies have highlighted the benefit of epigenetic modification by histone deacetylase inhibitor (HDACi) application to dental pulp cells (DPCs), which induces changes to chromatin architecture, promoting gene expression and cellular-reparative events (Duncan et al., 2013 [3]; Paino et al., 2014 [4]). In this study a genome-wide transcription profiling in epigenetically-modified mineralizing primary DPC cultures was performed, at relatively early and late time-points, to identify differentially regulated transcripts that may provide novel therapeutic targets for use in restorative dentistry. Here we provide detailed methods and analysis on these microarray data which has been deposited in Gene Expression Omnibus (GEO): GSE67175.en
dc.format.extent391en
dc.format.extent393en
dc.language.isoenen
dc.relation.ispartofseriesGenomic Dataen
dc.relation.ispartofseries5en
dc.rightsYen
dc.subjectDental pulp cellsen
dc.subjectEndodonticsen
dc.subjectEpigeneticsen
dc.subjectHistone deacetylase inhibitorsen
dc.subjectMineralizationen
dc.titleTranscriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time pointsen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/hduncanen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/gmoranen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fleminggen
dc.identifier.rssinternalid106082en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDTagMolecular Biologyen
dc.identifier.orcid_id0000-0001-8690-2379en


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