dc.contributor.author | ROWAN, MICHAEL | en |
dc.date.accessioned | 2016-06-22T12:19:21Z | |
dc.date.available | 2016-06-22T12:19:21Z | |
dc.date.created | 2014 | en |
dc.date.issued | 2014 | en |
dc.date.submitted | 2014 | en |
dc.identifier.citation | Klyubin, I. Nicoll, A.J. Khalili-Shirazi, A. Farmer, M. Canning, S. Mably, A. Linehan, J. Brown, A. Wakeling, M. Brandner, S. Walsh, D.M. Rowan, M.J. Collinge, J., Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity, Journal of Neuroscience, 34, 18, 2014, 6140 - 6145 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/76581 | |
dc.description.abstract | Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD neuropathogenesis. Here, we show that intravascular administration of a high-affinity humanized anti-PrP antibody to rats can prevent the plasticity-disrupting effects induced by exposure to soluble AD brain extract. These results provide an in vivo proof of principle for such a therapeutic strategy. | en |
dc.format.extent | 6140 | en |
dc.format.extent | 6145 | en |
dc.relation.ispartofseries | Journal of Neuroscience | en |
dc.relation.ispartofseries | 34 | en |
dc.relation.ispartofseries | 18 | en |
dc.rights | Y | en |
dc.subject | Alzheimer's disease | en |
dc.title | Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mrowan | en |
dc.identifier.rssinternalid | 101710 | en |
dc.identifier.doi | http://dx.doi.org/10.1523/JNEUROSCI.3526-13.2014 | en |
dc.rights.ecaccessrights | openAccess | |
dc.identifier.rssuri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84899637070&partnerID=40&md5=33dee5f380c0c5f88807952c2c4cd6ed | en |