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dc.contributor.authorHARDIMAN, ORLAen
dc.contributor.authorROONEY, JAMESen
dc.date.accessioned2016-06-22T12:19:08Z
dc.date.available2016-06-22T12:19:08Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationElisabetta Pupillo, Paolo Messina, Giorgia Giussani, Giancarlo Logroscino, Stefano Zoccolella, Adriano Chio, Andrea Calvo, Massimo Corbo, Christian Lunetta, Benoit Marin, Douglas Mitchell, Orla Hardiman, James Rooney, Zorica Stevic, Monica Bandettini di Poggio, Massimiliano Filosto, Maria Sofia Cotelli, Michele Perini, Nilo Riva, Lucio Tremolizzo, Eugenio Vitelli, Danira Damiani, and Ettore Beghi and the EURALS Consortium, Physical Activity and Amyotrophic Lateral Sclerosis: A European Population-Based Case Control Study, Annals of Neurology, 75, 5, 2014, 708 - 716en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/76579
dc.descriptionPUBLISHEDen
dc.description.abstractOBJECTIVE: To assess whether physical activity is a risk factor for amyotrophic lateral sclerosis (ALS). METHODS: From February 2008 to April 2012, 652 patients with ALS from European population-based registries (France, Ireland, Italy, United Kingdom, Serbia) and 1,166 population controls (matched for age, sex, and residency) were assessed. Upon direct interview, data were collected on occupation and history of sport and leisure activities, physical activity, and accidental injuries. Physical exercise was defined as having spent time doing activities that caused an individual to breath hard at least once per month and was coded as none, job-related, and/or sport-related. Sport-related and work-related physical exercise were quantified using metabolic equivalents (METs). Risks were calculated using conditional logistic regression models (adjusting for age, country, trauma, and job-related physical activity) and expressed as odds ratios (ORs) and adjusted ORs (Adj ORs) with 95% confidence intervals (CIs). RESULTS: Overall physical activity was associated with reduced odds of having ALS (Adj OR=0.65, 95% CI=0.48-0.89) as were work-related physical activity (Adj OR=0.56, 95% CI=0.36-0.87) and organized sports (Adj OR=0.49, 95% CI=0.32-0.75). An inverse correlation was observed between ALS, the duration of physical activity (p=0.0041), and the cumulative MET scores, which became significant for the highest exposure (Adj OR=0.34, 95% CI=0.21-0.54). An inverse correlation between ALS and sport was found in women but not in men, and in subjects with repeated traumatic events. INTERPRETATION: Physical activity is not a risk factor for ALS and may eventually be protective against the disease.en
dc.format.extent708en
dc.format.extent716en
dc.language.isoenen
dc.relation.ispartofseriesAnnals of Neurologyen
dc.relation.ispartofseries75en
dc.relation.ispartofseries5en
dc.rightsYen
dc.subjectphysical activityen
dc.titlePhysical Activity and Amyotrophic Lateral Sclerosis: A European Population-Based Case Control Studyen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rooneyj4en
dc.identifier.peoplefinderurlhttp://people.tcd.ie/hardimaoen
dc.identifier.rssinternalid100166en
dc.identifier.doihttp://dx.doi.org/10.1002/ana.24150en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeAgeingen
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDTagAMYOTROPHIC LATERAL SCLEROSISen
dc.subject.TCDTagAge related diseasesen
dc.subject.TCDTagEpidemiologyen
dc.subject.TCDTagRISK FACTORSen
dc.identifier.rssurihttp://onlinelibrary.wiley.com/doi/10.1002/ana.24150/abstract?deniedAccessCustomisedMessage=&userIsAuthenticated=falseen


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