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dc.contributor.authorWALSH, THOMASen
dc.date.accessioned2016-06-21T14:12:23Z
dc.date.available2016-06-21T14:12:23Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationCai B, Allexandre D, Rajagopalan V, Jiang Z, Siemionow V, Ranganathan VK, Davis MP, Walsh D, Dai K, Yue GH., Evidence of Significant Central Fatigue in Patients with Cancer-Related Fatigue during Repetitive Elbow Flexions till Perceived Exhaustion, PLoS One, 9, 12, 2014en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/76572
dc.description.abstractOBJECTIVE: To investigate whether fatigue induced by an intermittent motor task in patients with cancer-related fatigue (CRF) is more central or peripheral. METHODS: Ten patients with CRF who were off chemo and radiation therapies and 14 age-matched healthy controls were enrolled. Participants completed a Brief Fatigue Inventory (BFI) and performed a fatigue task consisting of intermittent elbow-flexion contractions at submaximal (40% maximal voluntary contraction) intensity till self-perceived exhaustion. Twitch force was elicited by an electrical stimulation applied to the biceps brachii muscle. The relative degree of peripheral (muscle) vs. central contribution to fatigue induced by the intermittent motor task (IMT) was assessed using twitch force ratio (TF ratio) defined as post IMT twitch force to pre IMT twitch force. The total number of trials (intermittent contractions) and total duration of all trials performed by each subject were also quantified. RESULTS: BFI scores were higher (p < 0.001) in CRF than controls, indicating greater feeling of fatigue in CRF patients than controls. A significantly smaller number of trials and shorter total duration of the trials (p < 0.05) were observed in CRF than control participants. The TF ratio (0.81 ± 0.05) in CRF was higher (p < 0.05) compared with that of controls (0.62 ± 0.05), suggesting CRF patients experienced a significantly lower degree of muscle (peripheral) fatigue at the time of perceived exhaustion. CONCLUSION: Consistent with prior findings for fatigue under submaximal sustained contraction, our results indicate that motor fatigue in CRF is more of central than peripheral origin during IMT. Significant central fatigue in CRF patients limits their ability to prolong motor performance.en
dc.language.isoenen
dc.relation.ispartofseriesPLoS Oneen
dc.relation.ispartofseries9en
dc.relation.ispartofseries12en
dc.rightsYen
dc.subjectCanceren
dc.titleEvidence of Significant Central Fatigue in Patients with Cancer-Related Fatigue during Repetitive Elbow Flexions till Perceived Exhaustionen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/walshtden
dc.identifier.rssinternalid99618en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeCanceren
dc.subject.TCDTagSYMPTOMSen


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