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  • T cells in experimental autoimmune encephalomyelitis 

    Lalor, Stephen (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)
    Multiple sclerosis (MS) is an intlammatory, demyelinating disease of the central nervous system (CNS) that is both clinically and pathologically heterogeneous. Studies in experimental autoimmune encephalomyelitis (EAE), ...
  • T. H. White: A Critical Biography 

    THOMPSON, ANNE (Trinity College Dublin. School of English. Discipline of English, 2018)
    This thesis is a critical biography of the author T. H. White. My purpose is to define the influences on his work throughout his life and set him in the historical and cultural context of the period from the 1930s through ...
  • Tadhg mac Gearóid Uí Rodaighe agus a mhuintir 

    Mac Muirí, Seosamh (Trinity College (Dublin, Ireland). Department of Irish and Celtic Studies, 2004)
    Rinneadh an taighde ar an teidil réamhluaite trí mhórán lámhscríbhinní sna hinstitiúidí éagsúla, Is. TCD H. 6. 15. go príomha, a chóipeáil, de scríobh láimhe agus a iniúchadh go mion le linn na hoibre sin féin agus ina ...
  • Taking advantage of correlated information for energy-aware scheduling in the IoT: A deep reinforcement learning approach 

    HRIBAR, JERNEJ (Trinity College Dublin. School of Engineering. Discipline of Electronic & Elect. Engineering, 2020)
    Millions of battery-powered sensors deployed for monitoring purposes in a multitude of scenarios, e.g., agriculture, smart cities, industry, etc., require energy-efficient solutions to prolong their lifetime. When these ...
  • Taking Liberties : entrepreneurial governance and gentrification in inner Dublin 

    Kelly, Sinéad (Trinity College (Dublin, Ireland). Department of Geography, 2008)
    This thesis is centrally concerned with the relationship between capital, the state and disadvantaged inner-city communities. The overall objective of this research is to review the structural forces underlying the recent ...
  • A Tale of Two Heteronormative sites: Considering Militaries and (Video)Gaming 

    Devlin, Ciaran Michael (Trinity College Dublin. School of Social Sciences & Philosophy. Discipline of Sociology, 2021)
    This thesis explores two sites that have traditionally been associated with heteronormative masculinity (militaries and videogames). Through the use of qualitative methodologies, it seeks to unearth and examine the ways ...
  • Talking about space : the Spatial Reference System of Irish English 

    Lucek, Stephen (Trinity College (Dublin, Ireland). Centre for Language and Communication Studies, 2015)
    This thesis has three central goals. The first is to establish a system for how people used to talk about space in previous studies of Irish English. This Is done through constructing a Spatial Reference System from extant ...
  • The Tamura Cycloaddition: Mechanism and Enantiocontrol 

    LOCKETT-WALTERS, BRUCE (Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)
    This thesis documents attempts to employ succinimide derivatives as ‘anhydride surrogates’ in the organocatalytic cycloaddition between aryl succinic anhydrides and various electrophiles previously developed in our research ...
  • Tandem language learning on the Internet : theory, tool development and empirical exploration 

    Appel, Marie Christine (Trinity College (Dublin, Ireland). Centre for Language and Communication Studies, 2004)
    The objective of this thesis is to investigate and advance the use of electronic mail for tandem language learning. Earlier research raised the following primary issues. Firstly, there were some organizational problems ...
  • Targeted bone remodelling : investigating the scissors model 

    Dooley, Clodagh M. (Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)
    Bone is continually being removed and replaced through the actions of basic multicellular units (BMU). This constant upkeep is necessary to remove microdamage and thus maintain the integrity of the bone. Microdamage forms ...
  • Targeting DNA : synthesis, biophysical and biochemical studies of new aminoalkyl derivatives of diphenyl guanidines and acridine 

    McKeever, Caitriona (Trinity College (Dublin, Ireland). School of Chemistry, 2012)
    Research on the design and synthesis of DNA targeting molecules is widespread. There are a number of diseases which are treated using DNA-targeting agents. DNA ligands have been shown to exhibit anticancer, antiprotozoal, ...
  • Targeting glial B2-adrenoceptors for immunododulation & neuoprotection in a rat model of Parkinson's disease 

    O'NEILL, EOIN (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)
    Neuro-inflammation is a key contributor to the pathogenesis of Parkinson’s disease (PD). Brain-resident microglia are dynamic cellular effectors of inflammation-mediated neurodegeneration in the Parkinsonian brain. Here ...
  • Targeting Synthetic Advances in Extended Phenanthrene and Phenanthroline Systems 

    CONWAY-KENNY, ROBERT (Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2018)
    The work herein describes the synthesis of a number of extended phenanthrene and phenanthroline systems as ligands, their Ru(II) and Ir(III) metal complexes, nitrogen-substituted graphene nanoribbons (N-GNRs), and as ...
  • Targeting the NMDA receptor/NO signalling pathway following L-α aminoadipic acid-induced astrocytic impairment and associated changes in the structural plasticity of neurons 

    DAVID, JENNIFER (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)
    This investigation firstly aims to characterise the impact of astrocytic dysfunction on neurons in vitro, specifically the effects of L-α amino adipic acid (L-AAA)-induced astrocytic dysfunction on neurite outgrowth and ...
  • Targeting the noradrenergic system for anti-inflammatory and neuroprotective actions in an animal model of Parkinson's disease 

    Yssel, Justin David (Trinity College (Dublin, Ireland). Department of Physiology, 2015)
    Parkinson's disease (PD) is a common neurodegenerative disorder that is characterised by the selective loss of dopamine (DA) neurons within the substantia nigra pars compacta and results in reduced striatal DA input ...
  • Targeting the Sphingosine 1-Phosphate Axis as a Therapeutic Strategy in Krabbe's Disease: A Pre-Clinical Study. 

    BECHET, SIBYLLE (Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)
    Krabbe's disease (KD, globoid cell leukodystrophy) is a rare infantile neurodegenerative disorder, caused by the defective gene galc encoding the lysosomal hydrolase galactosylceramidase (GALC). A subsequent decreased ...
  • TATUS A Ubiquitous Computing Simulator 

    O'Neill, Eleanor (Trinity College Dublin. Department of Computer Science, 2004-09)
    ?... we are trying to conceive a new way of thinking about computers in the world, one that takes into account the natural human environment and allows the computers themselves to vanish into the background? - Mark Weiser, ...
  • Tax planning by firms and tax competition by goverments 

    Moore, Padraig J. (Trinity College (Dublin, Ireland). Department of Economics, 2008)
    This thesis investigates tax planning by firms and tax com petition by governments. We begin in Chapter 1 by outlining the background, motivation and plan of the thesis. Chapter 2 reviews the relevant existing literature. ...
  • Taxation and political models 

    Yoder, Seán (Trinity College (Dublin, Ireland). Department of Economics, 2013)
    This thesis is a collection of three separate essays. Each essay deals with taxation policy directly or the expectation of future taxation by an electorate during a time of war. In terms of taxation, this essay generally ...
  • A taxonomic revision of the genus Henckelia Spreng. (Gesneriaceae) in Thailand and surrounding countries 

    Sirimongkol, Sukontip (Trinity College Dublin. School of Natural Sciences. Discipline of Botany, 2020)
    Henckelia was described in 1817 by Sprengel. The name Henkelia honours a German administrator and amateur botanist, L.V.F. Henckel von Donnersmarck (1785-1861). Currently Henckelia contains 68 species globally. This ...