Browsing Trinity College Dublin Theses & Dissertations by Title
Now showing items 1538-1557 of 6303
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Development of novel porous materials via polymer self-assembly and phase separation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2023)Polymer self-assembly is an ever-growing field that is attracting interest from a diverse range of research topics, which include the production of functional devices and membranes for electronic, optical and energy ... -
Development of novel pyrrolo-1,5-benzoxazepines as anti-cancer agents for the treatment of chronic myeloid leukaemia
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)Chronic myeloid leukaemia (CML) is characterised by the presence of a constitutively active tyrosine kinase known as Bcr-Abl. The Bcr-Abl kinase inhibitor, STI571, is the first line treatment for CML, but the recent emergence ... -
Development of Novel Thiol-ene Ligation Strategies for Thiosugar and Peptide Synthesis
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)This thesis, entitled ?Novel Thiol-ene Ligation Strategies for Thiosugar and Peptide Synthesis?, is composed of 6 Chapters. The first chapter gives an overview of the radical-mediated thiol-ene and thiol-yne addition ... -
Development of predictive control strategies for building climate control
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2018)The rapid growth in energy usage and CO2 emissions has become a critical issue for the whole world. It is noteworthy that buildings are a major contributor to global primary energy consumption. Among building services, use ... -
The development of radical methodologies for the syntehsis of thiolactones and carbon-sulfer bond formation
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)This thesis entitled "The Development of Radical Methodologies for the Synthesis of Thiolactones and Carbon-Sulfur Bond Formation" is divided into 7 chapters in which Chapter 1, the introduction, presents an overview of ... -
Development of salmon calcitonin (sCT) nanoporous / nanoparticulate microparticles for pulmonary delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis focus on the development and production by spray drying of porous microparticulate systems designed for the pulmonary delivery of a therapeutic peptide - salmon calcitonin. The nanoporous/nanoparticulate ... -
Development of SFV-based plasmid electroporation for use in tumour treatment and vaccine delivery
(Trinity College (Dublin, Ireland). Department of Microbiology, 2008)Electroporation is the delivery of short and intense electric pulses into living cells (either in tissue or suspension), which results in a transient and reversible increase in permeability of the cell transmembrane. This ... -
Development of Stimuli-responsive Materials for Direct Laser Writing for the Realisation of Microactuators
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2024)Two-photon polymerisation (2PP) is a laser-based fabrication technology which can be used to fabricate complex 3D microstructures with feature sizes ~100 nm. This thesis assesses the state of the art in 2PP and presents ... -
Development of Supramolecular Coordination Materials Using Naphthalimide and 2,6-bis(triazol-4-yl)pyridine Motifs
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)Structural coordination chemistry can be ultilised to develop functional supramolecular materials such as coordination polymers, soft materials, and metal organic frameworks. By applying the principles of self-assembly an ... -
DEVELOPMENT OF SUSTAINABLE, ALKALI-ACTIVATED BINDERS FOR CONSTRUCTION
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2023)This work contributes to the design and production of alkali-activated materials (AAMs) of lower environmental impact than Portland cement (PC) products. AAM binders result from the reaction of an activator and a precursor. ... -
Development of Synthetic Peptides as Functional Probes for the Lipoprotein Biosynthesis Pathway in Bacteria
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)Protein lipidation is a critical post-translational modification that occurs in all bacteria. The essential enzymes involved in this modification are exclusive to bacteria and have demonstrated potential as antibiotic ... -
Development of synthetic strategies towards multiporphyrin arrays
(Trinity College (Dublin, Ireland). School of Chemistry, 2011)The aim of this research was to develop synthetic strategies for the construction of multiporphyrin arrays with enhanced π-conjugation. Porphyrin oligomers with extended conjugation display a bathochromic shift in their ... -
Development of the beta-lactam structure as a scaffold for biologically active compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Tamoxifen is a selective estrogen receptor modulator (SERM) with a triarylethylene structure which acts as an estrogen antagonist in the breast. This drug is used extensively as an endocrine treatment for breast cancer, ... -
Development of the recombinant Semliki Forest virus vector as a gene therapy agent for the central nervous system
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2004)Multiple sclerosis (MS) is a neurological disease of the central nervous system (CNS), and a major cause of disability in young adults. It is characterized by the presence of inflammatory infiltrates containing autoreactive ... -
Development of the RISKRES: Screening for risk factors and resilience contributing towards suicidality in adolescents and young people
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2019)Youth suicide is a societal issue which warrants attention. The purpose of this study was to develop a psychometrically sound method to measure both risk factors and resilience as potential predictors of suicidality for ... -
Development of Unconventional Amide Bond Forming Methodologies
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2020)A novel methodology for the protection of amines and diamines using 2,2-pyridil, under the influence of N-heterocyclic carbene (NHC) catalysis, has been developed. Extensive experimentation which included the design and ... -
The development, implementation and evaluation of frailty assessment in oncology
(Trinity College Dublin. School of Medicine. Discipline of Radiation Therapy, 2020)Over the last number of decades, treatment outcomes from cancer care have improved dramatically. However, these improvements have mostly benefitted younger patients, or relatively robust older adults, rather than the entire ... -
Development, modelling and characterization of metal micro-textured thermal interface materials
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2010)A metal micro-textured thermal interface material (MMT-TIM) has been developed to address the shortcomings of conventional TIMs. In the present study, the MMT-TEVIs consist of silver foils with raised, small-scale, hollow ... -
Development, validation and optimisation of a vHTS protocol for identification of estrogen receptor modulators
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)The discovery of small-molecule drugs has reached a critical point in time where the number of new drugs released to market has become static regardless of the technological advances observed over the last few years. ... -
A Device Gateway Service Architecture as a Business Process Integration Enabler in Industry Automation Environments
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2019)Device gateways as a means of being an abstraction or transparency layer between devices and applications are in use already for a long time in the industry automation area to convert data formats, signals and messages ...