Synthesis of cyclic guanidines: 2-arylamino-1,4,5,6-tetrahydropyrimidines
Item Type:Journal Article
Citation:J. Shaw, I. Rozas, D.H. Grayson, Synthesis of cyclic guanidines: 2-arylamino-1,4,5,6-tetrahydropyrimidines, Arkivoc, ii, 2014, 161-174
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Considering the biological and chemical relevance of guanidine containing derivatives, we have devised a novel and efficient two-step synthesis of 2-arylamino-1,4,5,6-tetrahydropyrimidines. We have found that the coupling of aryl bromides with 2-aminopyrimidine is a very effective method for the high yielding synthesis of 2-arylaminopyrimidines. Moreover, the employment of Pd-catalysed hydrogenation to selectively reduce the pyrimidine ring generates a very high- yielding pathway to 2-arylamino-1,4,5,6-tetrahydropyrimidines of biological interest.
Type of material:Journal Article
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